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KMID : 1161420170200080790
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Journal of Medicinal Food
2017 Volume.20 No. 8 p.790 ~ p.796
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Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)
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Kolundzic Marina
Stanojkovic Tatjana
Radovic Jelena
Tacic Ana
Dodevska Margarita
Milenkovic Marina
Sisto Francesca
Masia Carla
Farronato Giampietro
Nikolic Vesna
Kundakovic Tatjana
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Abstract
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Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32?μg/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26?±?1.24?134.79?±?0.01?μg/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25?mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, β-glucans, and polyphenolic compounds.
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KEYWORD
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antibacterial activity, ACE inhibitory activity, β-glucan, Cantharellus cibarius, cytotoxicity
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